Previous studies found that 18F or 68Ga-labeled modified HER2 affibody with a novel hydrophilic linker, [18F]FAl/[68Ga]Ga-NOTA-Cys-GGGRDN-ZHER2:342 (denoted as [18F]FAl/[68Ga]Ga-NOTA-Cys-MZHER2), owned satisfactory specific tumor uptakes and favorable tumor-to-muscle and tumor-to-blood ratios during 4 h after injection [32, 33]. The gene discussed is ERBB2; the disease is neoplasm.