The development of hepatic steatosis in offspring exposed to a maternal high-fat diet is also related to a reduction in the expression of antioxidant defence genes, such as Cu/Zn superoxide dismutase (Sod1) and glutathione peroxidase-1 (Gpx1) and an increase in genes involved in the cellular senescence pathway, such as p16 [99]. The gene discussed is SOD1; the disease is Hepatic steatosis.