CASP4 and graft versus host disease: There was also increased mRNA expression of GVHD and rejection biomarkers CCL8, CXCL11, IDO1, WARS, and ISGs, as well as inflammasome-associated transcripts AIM2, IFI16, and GSDMD, although there was no significant increase in the expression in CASP1, CASP4, or CASP5 in monocytes infected with UV-inactivated CMV (table S7).