These include pathways regulating phagocytosis of fungal pathogens in the context of diminished expression of fungal PRRs CD36, MRC1, and complement receptor 3; induction of AIM2, IFI16, and pyrin inflammasomes; and up-regulation of mediators of chronic inflammation, which could be biomarkers for allograft dysfunction, rejection, and GVHD in transplantation. The gene discussed is IFI16; the disease is graft versus host disease.