NPPB and heart failure: The DANISH study randomized 556 NICM patients with symptomatic heart failure (NYHA class II/III), LVEF ≤ 35%, and elevated brain natriuretic peptide levels to receive either ICD therapy or routine medical care.14 Of note, this contemporary cohort were treated optimally with proven heart failure therapies, with more than 92% receiving β-blockade and renin-angiotensin system inhibitors, in excess of 57% on mineralocorticoid antagonists, and 93% of patients with left bundle branch block in excess of 150 ms receiving cardiac resynchronization therapy (CRT).