RYR2 and Ventricular arrhythmia: Allele-specific silencing using adeno-associated virus small interfering RNA duplexes has been shown to suppress the mutant RyR2 messenger RNA (RyR2-R4496C) with no significant effect on wild-type levels, correlating with a reduction in delayed afterdepolarizations, ventricular arrhythmias, and ultrastructural abnormalities in treated animals.70