CACNA1C and autosomal dominant disease: It is an autosomal-dominant disease with five identified causative genes, including three that encode for K+ channels (KCNH2, KCNQ1, and KCNJ2) and two that encode for subunits of the L-type Ca2+ channels (CACNA1C and CACNB2).49–51 Mutations in the CaV1.2 genes CACNA1C and CACNB2b have also been associated with both idiopathic ventricular fibrillation and early repolarization syndrome.43