It is an autosomal-dominant disease with five identified causative genes, including three that encode for K+ channels (KCNH2, KCNQ1, and KCNJ2) and two that encode for subunits of the L-type Ca2+ channels (CACNA1C and CACNB2).49–51 Mutations in the CaV1.2 genes CACNA1C and CACNB2b have also been associated with both idiopathic ventricular fibrillation and early repolarization syndrome.43 This evidence concerns the gene CACNA1C and early repolarization associated with ventricular fibrillation.