pylori is considered as a major cause of peptic ulcer and mucosa associated lymphoid tissue lymphoma or gastric cancer.5 Although, gastritis to gastric cancer development is a rare state, various studies reported that IL-1 and tumor necrosis factor- alpha (TNF-α) polymorphism along with H. pylori infection are predisposing risk factors for gastric carcinoma.6H. The gene discussed is TNF; the disease is peptic ulcer disease.