Therefore, they can help in identifying more potent biomarkers using dysregulated pathways.13 We used a network-based method to ascertain the dysregulated pathways elaborated in hepatitis C which may build new insights into pathogenesis of liver fibrosis.18TGF-β/Smad signaling pathway is known to be one of the key fibrogenic and inflammatory pathways in the liver.19 TGF-β1 have been implicated in the process of activating HSCs with the magnitude of fibrosis being in proportion to increase in TGF β levels. This evidence concerns the gene TGFB1 and Hepatic fibrosis.