In a very recent study by Ursini et al found NAFLD prevalence of (25%) and suggested complement factor C3 as potential biomarker for NAFLD.20 In a meta-analysis conducted by Young-Ho lee et al about genetic association of NAFLD in RA and psoriatic arthritis found that PPARg Pro12Ala polymorphism is associated with susceptibility to NAFLD in East Asians, but not in European populations.21 In Chinese study on general population fatty liver prevalence was (24.7%) with strong association of certain metabolic traits like, higher body fat, obesity, dyslipidemia raised fasting blood sugar levels.22 The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.