TNF and autoimmune disease: According to findings of our study, most of markers of inflammation showed positive correlation with pollutants, Our study results have elaborated the Th1/Th2 derived pro inflammatory cytokines (TNF-α, TNF-β and IL-6), since the study population was healthy subjects increase in serum concentration at subclinical level is a frightening condition given that constant rise of inflammatory markers can lead to systemic diseases including autoimmune disease and even cancer.