LDHA and pancreatic neoplasm: Since our previous study showed a synergistic interaction of LDH-A inhibitors with gemcitabine against pancreatic cancer cell lines in hypoxia,17 we explored the cytotoxic effects of NHI-Glc-2 in combination with gemcitabine on MesoII and STO cells, cultured under normoxic and hypoxic conditions (1% O2), as well as cells growing as adherent monolayers or spheroids.