A recent meta-analysis showed that elevated serum LDH-A levels prior to chemotherapeutic treatment, are a significant prognostic factor in malignant mesothelioma.57 However, to the best of our knowledge, the current research is the first study to demonstrate the prognostic role of LDH-A protein expression in tumour tissues from both MPM and DMPM patients. This evidence concerns the gene LDHA and malignant mesothelioma.