Lactate production also contributes to extracellular acidosis, thus supporting tumour invasiveness and exerting immunosuppressive effects.45 This has raised interest regarding the mechanisms underlying regulation of LDH-A in cancer cells, including critical post-transcriptional modifications.48,49 Importantly, the results of the present study also suggest that low PCFT expression levels might directly or indirectly stimulate the enhanced expression of LDH-A, though the mechanism by which this occurs remains unclear. Here, SLC46A1 is linked to neoplasm.