PLA2R1 and acute lymphoblastic leukemia: ALL relapse samples exhibited a significantly increased PLA2R1 methylation of 65% ± 23% in comparison to samples taken from patients in remission (p < 0.001) and also compared to primary BCP-ALL (52% ± 22%), p < 0.001) and T-ALL (53% ± 24%), p = 0.02) samples (Supplementary Fig. 5A1).