SMARCA4 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: Importantly, the phenotype of our Brg1 KO mice closely resembles that of the FoxP3 KO mice, the classic model for IPEX disease, indicating that Brg1 KO is a valid model of IPEX-like disease, even though Brg1 is not a known autoimmune disease-associated gene in humans16.