Klf4 with Oct4 and Sox2 induces the expression of Lefty1 [151] and Nanog [152], KLF4 is also a prognostic predictor of colon cancer [153] and head neck squamous cell carcinoma [154], and is also detected in leukemia, myeloma, testis cancer [18], early stage breast cancer [155], nasopharyngeal cancer [156], and oral cancer [157]. Here, KLF4 is linked to head and neck squamous cell carcinoma.