In the MSA-P clinical sub-type we detected only one DEG (GPNMB), whereas in MSA-C the top genes were: PGAM2, ST5, STON1, RFTN1, ACTN1 and MMP14 (adj p < 1.0E-04; all upregulated) (Table 2; Fig. 2). The gene discussed is DENND2B; the disease is multiple system atrophy, cerebellar type.