Moreover, previous studies demonstrate that IGF promotes mitochondrial biogenesis and turnover in cancer cells by inducing peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), PGC-1α-related coactivator, nuclear factor-erythroid-derived 2-like 2 (NFE2L2/NRF2), and the mitophagy mediator BNIP3 [63]. This evidence concerns the gene NFE2L2 and cancer.