Whereas Ctrl-Wnt1 mice had a range of 1 to more than 4 nodules per section (most had more than 2 metastatic nodules), cKD-Wnt1 and cKO-Wnt1 mice had only 1 or 2 metastatic nodules per section (chi-square test, p (Ctrl-Wnt1 vs cKD-Wnt1) = 0.02, p (Ctrl-Wnt1 vs cKO-Wnt1) = 0.03). The gene discussed is CTRL; the disease is chronic kidney disease.