To determine the role of FAK and its kinase function in MMTV-Wnt1-driven basal-like mammary tumors, FAK floxed allele (FAKfl) [25, 9] and FAK kinase dead knock-in allele (FAKKD) [26, 27] were crossed with MMTV-Wnt1 and MMTV-Cre mice which express the Cre recombinase in mammary epithelial cells. This evidence concerns the gene PTK2 and breast cancer.