CCL20 and cancer: For example, CCL20, the expression/secretion of which was most markedly increased by EICD in both the RNA-seq (Fig. 5a) and protein arrays (Fig. 5b), is the ligand of CC chemokine receptor 6 (CCR6) [41] of which signaling has been demonstrated to induce the epithelial-to-mesenchymal transition (EMT), migration, invasion, tumorigenesis, and metastasis of various cancer cells [42–46].