The present study supports that TLRs (TLR4, TLR2) decrease and phosphorylated (active) IκB (p-IκB) and NF-κB p65 increase in COPD model rats, and further increase pro-inflammatory cytokines, while Feikang granules protect these inflammatory responses. The gene discussed is TLR2; the disease is chronic obstructive pulmonary disease.