In addition, dexamethasone also significantly decreased the expression of TNF-α and IL-6 in COPD rat pulmonary macrophages, which was similar to the high-dose Feikang granule group (P = 0.502; P = 0.396), and significantly increased the expression of TLR4 and TLR2. The gene discussed is TLR4; the disease is chronic obstructive pulmonary disease.