However, DNA methylation changes found here concerned ADAMTS2, ADAMTS14 and ADAMTS17. The over-expression of ADAMTS17, has been associated to increased cell growth in cancer cells [63], and its hypo-methylation and over-expression from RNAseq [28] are consistent with the proliferative phenotype we observed and increased expression of proteins involved in tissue remodeling, and alterations of cell structure and cell adhesion pathways found in the same cells [32]. Here, ADAMTS2 is linked to cancer.