In line with these findings, it was reported that the ratio of mBDNF to proBDNF increases in mice subjected to chronic unpredicted mild stress that exhibit depressive-like behaviors [43] as well as in a rat model of anxiety induced by intraplantar injections of complete Freund’s adjuvant and a model of depression induced by chronic restraint stress [44]. This evidence concerns the gene BDNF and depressive symptom measurement.