When it comes to aging and neurodegeneration, it was found that in neurons of 1) rat brain during physiological aging, 2) human AD brain, and 3) tauopathic mouse brain (a model of AD), CacyBP/SIP was present mainly in neuronal somata and co-localized with β-tubulin and tau protein [61,62]. The gene discussed is MAPT; the disease is Alzheimer disease.