As Zn2+ co-localizes with senile plaques in AD patients and there is evidence that AD-related cognitive decline depends on the level of extracellular Zn2+ [35], the ability of S100A6 to bind Zn2+ may, similarly as in the case of S100B [36], prevent Zn2+-induced toxicity. Here, S100A6 is linked to Alzheimer disease.