A later study by Boston et al. [62], with 15 AD patients (5 males, mean age: 83.5, mean MMSE score 20.4), 13 healthy controls (7 males, mean age: 80.8, mean MMSE score 29.1) and 13 vascular dementia patients (9 males, mean age: 81.8, mean MMSE score 18.4), found a decreasing trend in the activity of AChE within the AD cohort, however the differences were not statistically significant. The gene discussed is ACHE; the disease is Alzheimer disease.