Specific cerebrospinal (CSF) biofluid constituents, such as amyloid beta 42 (Aβ42), which correlates with extracellular senile plaques [7], total tau (T-tau), which reflects the intensity of neuronal damage [8] and phosphorylated tau (P-tau), which correlates with tangle pathology [8], were shown to have excellent diagnostic accuracy [9]. Here, MAPT is linked to Senile plaques.