The MB-MDR analysis suggested that that the four-locus model involving MDM4 rs4245739, TP53 rs1042522, MDM2 rs2279744, and MDM2 rs3730485 was significantly associated with increased odds of AML (p = 0.004) while the three-locus models involving MDM4 rs4245739, TP53 rs1042522, and MDM2 rs2279744 were significantly associated with a decreased odds of AML (p = 0.001). This evidence concerns the gene TP53 and acute myeloid leukemia.