Moreover, the combination of homozygous genotypes with the variant alleles of MDM4 rs4245739 and MDM2 rs3730485 decreased the odds of AML, while the combination of wildtype or heterozygous genotype of MDM4 rs4245739 with homozygous genotype with the variant allele of MDM2 rs3730485 increased the odds of AML. This evidence concerns the gene MDM2 and acute myeloid leukemia.