In age- and sex-adjusted analysis, high IGFBP-1 remained significantly associated with protection from incident diabetes in the overall cohort (HR 0.50, 95% CI 0.29–0.88, p = 0.02) and in men (HR 0.31, 95% CI 0.10–0.92, p = 0.03; Figure 6). The gene discussed is IGFBP1; the disease is diabetes mellitus.