However, when body mass index (BMI) and insulin levels were added to the model, the association between IGFBP-1 and diabetes was attenuated and no longer significant (HR 0.47, 95% CI 0.21–1.03, p = 0.06 in the overall cohort; HR 0.66, 95% CI 0.26–1.67, p = 0.38 in men). Here, INS is linked to diabetes mellitus.