AFP and hepatocellular carcinoma: In a previously published metanalysis comparing AFP, AFP-L3 and Des-γ-carboxy prothrombin (DCP) to detect a single HCC nodule of less than 5 cm, AUROCs were 0.65, 0.69, and 0.69 with corresponding cut-offs of >200 ng/mL, >15% and >40 mAU/mL, respectively [48].