UTRN and Duchenne muscular dystrophy: Additionally, a utrophin/dystrophin double KO mouse has a degenerative phenotype that is more like the human Duchenne muscular dystrophy phenotype [40] than the mdx mutation in mice, but all three of the genes with the greatest upregulation in the utrophin/dystrophin double KO mouse are among the four downregulated genes in mdm.