PIR and neoplasm: For example, piR-651 [67,68] and piR-55490 [69] promote tumor cell proliferation in lung cancer, piR-36712 [70] and piR-021285 [71] suppress cell proliferation and invasion in breast cancer, piR-1245 induces tumor growth and is a poor prognostic biomarker in colorectal cancer [72], and piR-52207 stimulates tumorigenesis in ovarian cancer [73].