For instance, the expression of HULC and H19 is triggered by oxidative stress to upregulate Interleukin-6 (IL-6) and the C-X-C chemokine receptor type 4 (CXCR4) sequestering Let-7a/b and miR-372/-373, respectively, to promote cholangiocarcinoma migration and invasion [165]. This evidence concerns the gene CXCR4 and cholangiocarcinoma.