For example, MSI testing may both be less specific in older patients (where somatic MLH1 hypermethylation is known to be more common in colorectal cancer [14]) and may be less sensitive to identify path_MSH6 and path_PMS2 cases (i.e., pathogenic variants in MSH6 and PMS2) [15]. The gene discussed is PMS2; the disease is colorectal cancer.