CXCL8 and chronic kidney disease: Further, markers of ED in CKD have been associated with the arterial stiffness [25], IL-8 driven vascular calcification [26] or the reduced microcirculation present in this population [27], which also contributes to the cardiovascular burden, as well as with the abnormal left ventricular structure and function [28,29,30] and, what is clinically relevant, to the increased mortality risk in CKD and ESRD [31,32,33,34,35].