TACR1 and neoplasm: As the bone marrow of leukemia patients expands (due to an abnormal increase in the number of white blood cells) and leads to bone pain [99,100], the authors of the study reported another important finding: the blockade of the NK-1R exerted an antinociceptive effect in myeloid leukemia-induced bone pain by promoting apoptosis in leukemia cells and by counteracting inflammatory mechanisms in the bone/tumor microenvironment (Table 2) [1].