NFKB1 and acute myeloid leukemia: Aprepitant also inhibits the formation of AML cell colonies and this NK-1R antagonist, when combined with chemotherapeutic drugs, is more effective in inducing cytotoxic effects and AML cell growth blockade: aprepitant, via suppression of anti-apoptotic target genes of NF-κB, sensitizes AML cells to chemotherapeutic drugs.