TACR1 and acute lymphoblastic leukemia: Another important finding is that aprepitant, in combination with chemotherapeutic drugs, was more effective in blocking cell growth and inducing cytotoxic effects and that this NK-1R antagonist exerted an antitumor action against acute promyelocytic leukemia (APL)-derived NB4 cells and pre-B acute lymphocytic leukemia (ALL)-derived Nalm-6 cells [87].