To date, in vitro and in vivo experiments have shown that the SP/NK-1R system, in a similar way, is involved in cancer progression in both solid (e.g., pancreas, lung, breast, osteosarcoma, retinoblastoma, glioma, neuroblastoma) and non-solid (AML) tumors. This evidence concerns the gene TACR1 and acute myeloid leukemia.