It has been reported that the truncated isoform mediates tumor cell malignancy, increases the growth of these cells and promotes the synthesis of cytokines which exert growth-promoting effects (activates NF-κB that up-regulates the truncated isoform but slightly increases the full-length form), whereas the full-length isoform induces slow cancer cell growth [94,95,96]. This evidence concerns the gene NFKB1 and cancer.