First, we found decreased glucose (p = 0.01), fasting insulin (p < 0.01) as well as ameliorated HOMA2-IR value (p < 0.02) in PCOS patients, but not in control women (p = 0.48, p = 0.70, p = 0.72) after isoflavone intervention. The gene discussed is INS; the disease is polycystic ovary syndrome.