PFIC represents a group of disorders (with subtypes grouped based on the underlying genetic deficiency; eg ATP8B1‐deficient PFIC, ABCB11‐deficient PFIC) in which disruption of bile homeostasis can eventually lead to cholestasis, cirrhosis, liver failure and death.12, 13, 14. This evidence concerns the gene ATP8B1 and progressive familial intrahepatic cholestasis.