P2RX7 and metabolic dysfunction-associated steatohepatitis: Indeed, the P2RX7+ cell pool comprised CD45+, CD14+, and CD68+ inflammatory cells (Figs 1B and S1A), and populations of cells expressing both CD45, CD14, or CD68 and P2RX7 increased by ~ 2.9-, ~ 6.9-, and ~ 10-fold, respectively, in NASH-affected livers compared to healthy control (Fig 1B).