CDKN2B and open-angle glaucoma: [43, 50] It has been shown that rs3217992 and rs1063192 affect miR-138-3p- and miR-323b-5p-mediated regulation of CDKN2B respectively and an allelic-specific regulation in these miRNA-binding sites is considered a potential mechanism, at least in part, to explain the association between the CDKN2B polymorphisms and POAG.