In the TCGA cohort, melanoma patients with MUC16 mutations had a significantly better overall survival (OS) than those without it (median OS: 104.5 [95% CI, 77.1-131.9] vs. 49.3 [95% CI, 42.6-55.9] months; Log rank test P < 0.001; Figure 4A). The gene discussed is MUC16; the disease is melanoma.