A total of 2537 genes were found to be Differentially expressed (DE) (P < 0.05) between normal and diabetic subjects; of them, seven up-regulated genes: PTPRC, PIK3R1, ATP6V1A, IL7 R, KRAS, USP8, and GLMN and nine down-regulated genes: SUMO1, PPARA, CDH23, TAT, PIK3 CD, RIMS2, LMF1, AKT2, and SREBF1 have already been reported in lipodystrophy or its various subtypes using Cytoscape app – DisGeNET v5.0 analysis. The gene discussed is SREBF1; the disease is lipodystrophy.