AR and lipodystrophy: Activation of ‘Androgen receptor signalling pathway’ has also been reported to inhibit fat mass in cultured 3T3-L1 cells [24] and therefore may cause lipodystrophy like symptoms; the androgen receptor interacts with β-catenin protein in the Wnt pathway, thereby bypassing the canonical Wnt signalling – which functions as an adipogenic switch that represses adipogenesis when activated and initiates adipogenesis when it is turned off.