Human papillomaviruses (HPVs) produce early protein 6 of HPVs protein in infected female cervical tissue cells to enhance signal transducer and activator of transcription 3 (STAT3) activation, which promotes microRNA‐223‐3p (miR‐223) transcription, leading to normal tissue to cervical squamous cancer transformation. Here, STAT3 is linked to cervical squamous cell carcinoma.