However, HMGCS1 was not significantly different in the defined group as shown in Fig. S3D. Analysis of TGFBR3 and HMGCS1 expression in clinical CSCC samples by IHC assays indicated that TGFBR3 and HMGCS1 were remarkably downregulated in tumor tissues compared with adjacent tissues (Fig. 6B). The gene discussed is HMGCS1; the disease is neoplasm.