GLP1R and Hirsutism: In terms of improving hirsutism and acne, Wang et al (27), Jensterle et al (18), and Ortega-Gonzalez et al (24) revealed that metformin, GLP-1 receptor agonists, TZDs, and metformin combined with TZDs could significantly improve hirsutism, but there were no statistical differences among the interventions.