The pathogenesis of PCOS is far from completely clear and may relate to hyperandrogenemia, hyperinsulinemia, an imbalanced ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH), metabolic aberrances, inflammation, advanced glycation end products, and endoplasmic reticulum stress (2-5). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.