Using the Cancer Genome Atlas (TCGA, available online: https://cancergenome.nih.gov/)13 database, the prognostic impact of p53 and NY‐ESO‐1 gene expression on esophageal squamous cell carcinoma (ESCC), gastric cancer, and hepatocellular carcinoma (HCC) can be evaluated. Here, TP53 is linked to hepatocellular carcinoma.