Using the Cancer Genome Atlas (TCGA, available online: https://cancergenome.nih.gov/)13 database, the prognostic impact of p53 and NY‐ESO‐1 gene expression on esophageal squamous cell carcinoma (ESCC), gastric cancer, and hepatocellular carcinoma (HCC) can be evaluated. The gene discussed is TP53; the disease is esophageal squamous cell carcinoma.