For patients with HCC to have a 70% chance of HCC‐specific survival 5 y after transplantation, their level of AFP should be <200 ng/mL and the sum of number and size of tumors should not exceed 7; if the level of AFP was 200‐400 ng/mL, should be ≤5; if their level of AFP was 400‐1000 ng/mL, should be ≤4. In the validation set, the model identified patients who survived 5 y after liver transplantation with 0.721 accuracy. This evidence concerns the gene AFP and hepatocellular carcinoma.