CXCL13 has been implicated in several autoimmune diseases by redistributing B lymphocytes into damaged tissues, reorganizing them into micro anatomic positions and possibly enhancing their activation through  B-cell receptors (10).The serum CXCL13 levels are raised in RA patients in comparison with healthy controls (32, 33). This evidence concerns the gene CXCL13 and rheumatoid arthritis.