AVP and Obesity: Additionally, plasma concentrations of MR-proADM were significantly higher among the non-obese patients with HF compared to the non-obese patients without HF and not among obese patients with HF, suggesting that obesity influence the plasma concentrations of MR-proADM and copeptin in patients without HF and that obese patients with early stages of HF have an overall impaired neurohormonal response.