In addition to the role of Nurr1 in the pathogenesis of dopamine-related neurological disorders [6, 13], several studies have revealed the involvement of Nurr1 in reward-seeking behavior [14], symptoms of schizophrenia [15], and pathogenesis of Alzheimer’s disease (AD) [16]. Here, NR4A2 is linked to early-onset autosomal dominant Alzheimer disease.