In relation to changes in Nurr1 expression in AD, the reduced number of Nurr1-expressing cells in subiculum of AD model mice with disease progress [64] and decreased levels of dopamine in various regions including the hippocampus of Nurr1 heterozygous mice, a schizophrenic animal model [15], may demonstrate some similarities in molecular changes involving both disorders as well as provide additional insights for further studies comparing mechanisms between two diseases. Here, NR4A2 is linked to Alzheimer disease.