Interestingly, activation of Nurr1 or the Nurr1:RXRα heterodimer by agonists such as AQ, SA00025, and BRF110 has been reported to diminish neuronal loss, neuroinflammation, and behavioral symptoms that occur in 6-hydroxydopamine or MPTP-induced PD models [19, 20, 221, 222]. The gene discussed is NR4A2; the disease is Parkinson disease.