Overexpression of UCHL1 decreased mouse double minute 2 (MDM2) levels, a factor involved in cancers, and increased the UPS-related proteins such as p53, p14, ADP-ribosylation factor (ARF), p27KIPI, ubiquitinated proteins, monoubiquitin, BE1, proteasome subunit alpha type 7 (PSMA7) and the proteasomal activity, the last five systems being implicated in auditory cortex senescence [49, 51]. The gene discussed is PSMA7; the disease is cancer.