Lnc AS Uchl1 (ubiquitin C-terminal hydrolase L1) intensifies translation of UCHL1, which plays an important role in the ubiquitin proteasome system (UPS) and in many other cellular processes such as differentiation, cell proliferation, as well as in brain function and in neurodegenerative diseases. This evidence concerns the gene UCHL1 and neurodegenerative disease.