Two lncRNAs, namely prostate cancer non-coding RNA 1 (PRNCR1) and prostate cancer gene expression marker 1 (PCGEM1), generally overexpressed in the most aggressive forms of prostate cancers, precisely bind to the androgen receptor (AR) and strongly amplify androgen receptor-mediated gene expression in both ligand-independent and dependent pathways [75]. The gene discussed is PCGEM1; the disease is prostate cancer.