Critically, this is the first demonstration that Oxyphylla A promotes A53T-α-syn degradation by activating the PKA/Akt/ mTOR/PSMB8 signaling pathway, resulting in the rescue of the neurotoxicity induced by accumulated A53T-α-syn in vitro and in vivo, with potential therapeutic application in PD treatment. This evidence concerns the gene AKT1 and Parkinson disease.