On the other hand, in the BCCAO model, which is known to induce global ischemia and subsequent delayed neuronal cell death, the induction of RAGE expression in the hippocampal vascular endothelial cells preceded that neurons and glia, indicating that endothelial RAGE could contribute to delayed neuronal death by enhancing vascular injuries, and potentially leading to microcirculatory disturbances [16]. This evidence concerns the gene AGER and ischemia.