As a result of this, it should be considered that clinical manifestation seen in PXE patients, like visual impairments or soft tissue calcification which are, thusfar, claimed to be direct results of aberrant concentrations of the unknown ABCC6 substrate, could also be indirect consequences caused by premature aging processes induced by e.g. an aberrant lipid metabolism due to ABCC6 deficiency [53]. Here, ABCC6 is linked to Pseudoxanthoma elasticum.