MIB2 and ischemia: Here, we found that 1) Mib2 is involved in LPS- and OGD-induced microglial activation; 2) Mib2 interacts with IKK complex proteins and transcriptionally regulates Notch signaling through NF-κB activation; 3) Microglial specific Mib2 knockout significantly alleviates microglial activation and ischemia-induced brain injury in mice, suggesting that Mib2 might be a potential therapeutic target.