CD226 and neoplasm: More specifically, Nectin-2 (PRR2, PVRL2, and CD112), a protein expressed by primary tumor cells, cell lines, and to a lesser extent on immune cells such as monocytes, macrophages, B cells, and dendritic cells, was shown to interact with DNAM-1 and/or TIGIT to alter the immune response (Human Cell Atlas,9,13).