Noteworthily, clinical trials targeting PVR and its interactions are either antibodies directed against TIGIT in combination with other mAbs or chemotherapy or radiation (refer to TIGIT section) or use PVR as a point of entry for recombinant oncolytic polioviruses in the case of advanced gliomas (NCT01491893, NCT03043391, and NCT02986178) or triple negative breast cancer (NCT03564782)9. Here, PVR is linked to central nervous system cancer.